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Antiretroviral treatment for adult HIV infection in 2002: Updated recommendations of the International AIDS Society-USA panel

Identifieur interne : 00B825 ( Main/Exploration ); précédent : 00B824; suivant : 00B826

Antiretroviral treatment for adult HIV infection in 2002: Updated recommendations of the International AIDS Society-USA panel

Auteurs : Patrick G. Yeni [France] ; Scott M. Hammer [États-Unis] ; Charles C. J. Carpenter [États-Unis] ; David A. Cooper [Australie] ; Margaret A. Fischl [États-Unis] ; Jose M. Gatell [Espagne] ; Brian G. Gazzard [Royaume-Uni] ; Martin S. Hirsch [États-Unis] ; Donna M. Jacobsen [États-Unis] ; David A. Katzenstein [États-Unis] ; Julio S. G. Montaner [Canada] ; Douglas D. Richman [États-Unis] ; Michael S. Saag [États-Unis] ; Mauro Schechter [Brésil] ; Robert T. Schooley [États-Unis] ; Melanie A. Thompson [États-Unis] ; Stefano Vella [Italie] ; Paul A. Volberding [États-Unis]

Source :

RBID : Pascal:02-0424250

Descripteurs français

English descriptors

Abstract

Objective New information warrants updated recommendations for the 4 central issues in antiretroviral therapy: when to start, what drugs to start with, when to change, and what to change to. These updated recommendations are intended to guide practicing physicians actively involved in human immunodeficiency virus (HIV)- and acquired immunodeficiency syndrome (AIDS)-related care. Participants In 1995, physicians with specific expertise in HIV-related basic science and clinical research, antiretroviral therapy, and HIV patient care were invited by the International AIDS Society-USA to serve on a volunteer panel. In 1999, others were invited to broaden international representation. The 17-member panel met regularly in closed meetings between its last report in 2000 and April 2002 to review current data. The effort was sponsored and funded by the International AIDS Society-USA, a not-for-profit physician education organization. Evidence and Consensus Process The full panel was convened in late 2000 and assigned 7 section committees. A section writer and 3 to 5 section committee members (each panel member served on numerous sections) identified relevant evidence and prepared draft recommendations. Basic science, clinical research, and epidemiologic data from the published literature and abstracts from recent (within 2 years) scientific conferences were considered by strength of evidence. Extrapolations from basic science data and expert opinion of the panel members were included as evidence. Draft sections were combined and circulated to the entire panel and discussed in a series of full-panel conference calls until consensus was reached. Final recommendations represent full consensus agreement of the panel. Conclusions Because of increased awareness of the activity and toxicity of current drugs, the threshold for initiation of therapy has shifted to a later time in the course of HIV disease. However, the optimal time to initiate therapy remains imprecisely defined. Availability of new drugs has broadened options for therapy initiation and management of treatment failure, which remains a difficult challenge.


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Le document en format XML

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<name sortKey="Schechter, Mauro" sort="Schechter, Mauro" uniqKey="Schechter M" first="Mauro" last="Schechter">Mauro Schechter</name>
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<name sortKey="Schooley, Robert T" sort="Schooley, Robert T" uniqKey="Schooley R" first="Robert T." last="Schooley">Robert T. Schooley</name>
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<name sortKey="Vella, Stefano" sort="Vella, Stefano" uniqKey="Vella S" first="Stefano" last="Vella">Stefano Vella</name>
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<placeName>
<settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Volberding, Paul A" sort="Volberding, Paul A" uniqKey="Volberding P" first="Paul A." last="Volberding">Paul A. Volberding</name>
<affiliation wicri:level="1">
<inist:fA14 i1="18">
<s1>University of California San Francisco and San Francisco Veterans Affairs Medical Center .</s1>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of California San Francisco and San Francisco Veterans Affairs Medical Center .</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">JAMA, the journal of the American Medical Association</title>
<title level="j" type="abbreviated">JAMA j. Am. Med. Assoc.</title>
<idno type="ISSN">0098-7484</idno>
<imprint>
<date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">JAMA, the journal of the American Medical Association</title>
<title level="j" type="abbreviated">JAMA j. Am. Med. Assoc.</title>
<idno type="ISSN">0098-7484</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>AIDS</term>
<term>Adult</term>
<term>Antiviral</term>
<term>Chemotherapy</term>
<term>Human immunodeficiency virus</term>
<term>Recommendation</term>
<term>Treatment</term>
<term>Treatment efficiency</term>
<term>Updating</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>SIDA</term>
<term>Virus immunodéficience humaine</term>
<term>Adulte</term>
<term>Mise à jour</term>
<term>Recommandation</term>
<term>Antiviral</term>
<term>Traitement</term>
<term>Chimiothérapie</term>
<term>Efficacité traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Adulte</term>
<term>Recommandation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Objective New information warrants updated recommendations for the 4 central issues in antiretroviral therapy: when to start, what drugs to start with, when to change, and what to change to. These updated recommendations are intended to guide practicing physicians actively involved in human immunodeficiency virus (HIV)- and acquired immunodeficiency syndrome (AIDS)-related care. Participants In 1995, physicians with specific expertise in HIV-related basic science and clinical research, antiretroviral therapy, and HIV patient care were invited by the International AIDS Society-USA to serve on a volunteer panel. In 1999, others were invited to broaden international representation. The 17-member panel met regularly in closed meetings between its last report in 2000 and April 2002 to review current data. The effort was sponsored and funded by the International AIDS Society-USA, a not-for-profit physician education organization. Evidence and Consensus Process The full panel was convened in late 2000 and assigned 7 section committees. A section writer and 3 to 5 section committee members (each panel member served on numerous sections) identified relevant evidence and prepared draft recommendations. Basic science, clinical research, and epidemiologic data from the published literature and abstracts from recent (within 2 years) scientific conferences were considered by strength of evidence. Extrapolations from basic science data and expert opinion of the panel members were included as evidence. Draft sections were combined and circulated to the entire panel and discussed in a series of full-panel conference calls until consensus was reached. Final recommendations represent full consensus agreement of the panel. Conclusions Because of increased awareness of the activity and toxicity of current drugs, the threshold for initiation of therapy has shifted to a later time in the course of HIV disease. However, the optimal time to initiate therapy remains imprecisely defined. Availability of new drugs has broadened options for therapy initiation and management of treatment failure, which remains a difficult challenge.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Catalogne</li>
<li>Grand Londres</li>
<li>Géorgie (États-Unis)</li>
<li>Latium</li>
<li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Barcelone</li>
<li>Londres</li>
<li>Paris</li>
<li>Rome</li>
<li>Sydney</li>
</settlement>
</list>
<tree>
<country name="France">
<region name="Île-de-France">
<name sortKey="Yeni, Patrick G" sort="Yeni, Patrick G" uniqKey="Yeni P" first="Patrick G." last="Yeni">Patrick G. Yeni</name>
</region>
</country>
<country name="États-Unis">
<noRegion>
<name sortKey="Hammer, Scott M" sort="Hammer, Scott M" uniqKey="Hammer S" first="Scott M." last="Hammer">Scott M. Hammer</name>
</noRegion>
<name sortKey="Carpenter, Charles C J" sort="Carpenter, Charles C J" uniqKey="Carpenter C" first="Charles C. J." last="Carpenter">Charles C. J. Carpenter</name>
<name sortKey="Fischl, Margaret A" sort="Fischl, Margaret A" uniqKey="Fischl M" first="Margaret A." last="Fischl">Margaret A. Fischl</name>
<name sortKey="Hirsch, Martin S" sort="Hirsch, Martin S" uniqKey="Hirsch M" first="Martin S." last="Hirsch">Martin S. Hirsch</name>
<name sortKey="Jacobsen, Donna M" sort="Jacobsen, Donna M" uniqKey="Jacobsen D" first="Donna M." last="Jacobsen">Donna M. Jacobsen</name>
<name sortKey="Katzenstein, David A" sort="Katzenstein, David A" uniqKey="Katzenstein D" first="David A." last="Katzenstein">David A. Katzenstein</name>
<name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D." last="Richman">Douglas D. Richman</name>
<name sortKey="Saag, Michael S" sort="Saag, Michael S" uniqKey="Saag M" first="Michael S." last="Saag">Michael S. Saag</name>
<name sortKey="Schooley, Robert T" sort="Schooley, Robert T" uniqKey="Schooley R" first="Robert T." last="Schooley">Robert T. Schooley</name>
<name sortKey="Thompson, Melanie A" sort="Thompson, Melanie A" uniqKey="Thompson M" first="Melanie A." last="Thompson">Melanie A. Thompson</name>
<name sortKey="Volberding, Paul A" sort="Volberding, Paul A" uniqKey="Volberding P" first="Paul A." last="Volberding">Paul A. Volberding</name>
</country>
<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
</region>
</country>
<country name="Espagne">
<region name="Catalogne">
<name sortKey="Gatell, Jose M" sort="Gatell, Jose M" uniqKey="Gatell J" first="Jose M." last="Gatell">Jose M. Gatell</name>
</region>
</country>
<country name="Royaume-Uni">
<region name="Angleterre">
<name sortKey="Gazzard, Brian G" sort="Gazzard, Brian G" uniqKey="Gazzard B" first="Brian G." last="Gazzard">Brian G. Gazzard</name>
</region>
</country>
<country name="Canada">
<noRegion>
<name sortKey="Montaner, Julio S G" sort="Montaner, Julio S G" uniqKey="Montaner J" first="Julio S. G." last="Montaner">Julio S. G. Montaner</name>
</noRegion>
</country>
<country name="Brésil">
<noRegion>
<name sortKey="Schechter, Mauro" sort="Schechter, Mauro" uniqKey="Schechter M" first="Mauro" last="Schechter">Mauro Schechter</name>
</noRegion>
</country>
<country name="Italie">
<region name="Latium">
<name sortKey="Vella, Stefano" sort="Vella, Stefano" uniqKey="Vella S" first="Stefano" last="Vella">Stefano Vella</name>
</region>
</country>
</tree>
</affiliations>
</record>

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